王东旭，男，博士，副教授，硕士研究生导师，1987年11月生，汉族，吉林永吉人，九三学社社员，主要从事食品营养与毒理学，食品营养与健康及其功能性食品开发等方面的研究。2015年6月于安徽农业大学毕业获得农学博士学位，2015年7月在安徽农业大学茶与食品科技学院参加工作，期间在茶树生物学与资源利用国家重点实验室在职博士后、助理研究员，2020年4月进入77779193永利工作，2021年7月晋升副教授。

个人通讯邮箱：wdx@just.edu.cn; 或 justwdx@163.com.

教学情况：

先后承担过食品质量与安全、食品卫生与营养学、食品科学与工程、粮食工程等本科专业的《食品营养学》、《食品毒理学》、《食品卫生学》、《营养科学与健康》等课程的教学工作。

科研情况：

近年来，先后主持中国科协“青年人才托举工程”1项、省自然科学基金项目2项，参与国家自然科学基金项目3项、安徽省重点研究与开发计划2项等多项省部级以上科研项目。在《Journal of Agricultural and Food Chemistry》、《Journal of Pineal Research》、《Redox Biology》、《Food Chemistry》、《Current Opinion in Food Science》、《Food Research International》、《Journal of Functional Foods》、《Food & Function》、《Food and Chemical Toxicology》、《Frontiers in Nutrition》、《食品工业科技》、《食品与发酵工业》、《食品质量安全检测学报》等本领域国内外重要期刊发表学术论文50余篇（SCI论文累计IF 195），其中第一和通讯作者学术论文30余篇。获批授权发明专利3件，参编John Wiley & Sons出版社《Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology》著作章节1部，先后指导及合作指导食品科学、食品营养与卫生学学术型硕士研究生5人。目前为《Molecules》[IF 4.927]客座编辑；食品科学与生物医药领域期刊《Food Chemistry》、《Food Research International》、《Food and Chemical Toxicology》、《Journal of Functional Foods》、《Food & Function》、《International Immunopharmacology》、《Frontiers in Nutrition》、《Antibiotics》、《Journal of Herbal Medicine》等的审稿人。

代表性获奖情况：

中国商业联合会科学技术奖三等奖（排名5/8）（2022）

安徽省科学技术奖三等奖（排名4/5）（2019）

中国茶叶学会青年科技奖（排名1/1）（2017）

代表性科研项目：

中国科协“青年人才托举工程”项目，YESS20170016，2017/01-2019/12，45万，主持

江苏省自然科学基金青年项目，BK20210881，2021/07-2024/06，20万，主持

安徽省自然科学基金青年项目，1708085QC79，2017/07-2019/07，8万，主持

国家自然科学基金面上项目，31972459，2020/01-2023/12，58万，参加3/9

国家自然科学基金青年项目，31601424，2017/01-2019/12，20万，参加3/7

安徽省重点研究和开发计划，1804b06020367，2018/03-2021/02，60万，参加4/8

安徽省重点研究和开发计划，1904b11020038，2019/01-2021/12，60万，参加4/9

安徽省自然科学基金面上项目，1408085MKL39，2015/01-2016/12，8万，参加3/6

代表性科研论文与著作：

1) Taotao Wang, Hong Xu, Ruixia Dong, Shanshan Wu, Yuanxin Guo*, Dongxu Wang*, Effectiveness of targeting the NLRP3 inflammasome by using natural polyphenols: A systematic review of implications on health effects. Food Research International. 2023, 165:112567. (SCI, JCR Q1, 中科院食品科技1区, IF 7.425#) (#为发表年影响因子, *为通讯作者)

2) Taotao Wang, Hong Xu, Yu Guo, Zhanming Li, Hua Ye, Liang Wu, Yuanxin Guo*, DongxuWang*, Perfluorodecanoic acid promotes adipogenesis via NLRP3 inflammasome-mediated pathway in HepG2 and 3T3-L1 cells. Food and Chemical Toxicology. 2023, 171:113520. (SCI, JCR Q1, 中科院医学2区, IF 5.572#)

3) Qiuyan Ban, Wenjing Chi, Yu Tan, Shiqiong Wang, Ning Li, Lianjun Song, Xianqing Huang*, Dongxu Wang*, et al., Melatonin improved glucose homeostasis is associated with the reprogrammed gut microbiota and reduced fecal levels of short-chain fatty acids in db/db mice. Food Science & Nutrition. 2023, 1:11-15. (SCI, JCR Q2, 中科院食品科技3区, IF 3.553#)

4) Yanyan Zhang, Yue Xi, Changshui Yang, Weijuan Gong, Chengyin Wang, Liang Wu*, Dongxu Wang*, Short-chain fatty acids attenuate 5-fluorouracil-induced THP-1 cell inflammation through inhibiting NF-κB/NLRP3 signaling via glycerolphospholipid and sphingolipid metabolism. Molecules. 2023, 28(2), 494. (SCI, JCR Q2, 中科院化学2区, IF 4.927#)

5) Yijun Wang, Tiantian Liu, Yanmei Xie, Na Li, Yan Liu, Jiaqiang Wen, Man Zhang, Wanjie Feng, Jinbao Huang, Yuanxin Guo, Tufy Kabbas Junior, Dongxu Wang*, et al., Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice. Food Research International. 2022, 162:112008. (SCI, JCR Q1, 中科院食品科技1区, IF 7.425#)

6) Dongxu Wang, et al., Recent advances in the effects of dietary polyphenols on inflammation in vivo: potential molecular mechanisms, receptor targets, safety issues, and uses of nano-delivery system and polyphenol polymers. Current Opinion in Food Science. 2022, 48:100921. (SCI, JCR Q1, 中科院农林科学2区, IF 9.8#)

7) Dongxu Wang, et al., Green tea polyphenols upregulate the Nrf2 signaling pathway and suppress oxidative stress and inflammation markers in D-galactose-induced liver aging in mice. Frontiers in Nutrition. 2022, 9:836112. (SCI, JCR Q1, 中科院农林科学2区, IF 6.59#)

8) Man Yan, Xiang Li, Chang Sun, Jiajun Tan, Yuanyuan Liu, Mengqi Li, Zishang Qi, Jiayuan He, Dongxu Wang*, et al., Sodium butyrate attenuates AGEs-induced oxidative stress and inflammation by inhibiting autophagy and affecting cellular metabolism in THP-1 cells. Molecules. 2022, 27(24), 8715. (SCI, JCR Q2, 中科院化学2区, IF 4.927#)

9) Chengxue Yi, Wen Sun, Longkun Ding, Man Yan, Chang Sun, Chen-guang Qiu, Dongxu Wang*, et al., Short-chain fatty acids weaken ox-LDL-induced cell inflammatory injury by inhibiting NLRP3/caspase-1 pathway and affecting cellular metabolism in THP-1 cells. Molecules. 2022, 27(24), 8801. (SCI, JCR Q2, 中科院化学2区, IF 4.927#)

10) Zhanming Li, Zhongyang Ren, Lin Zhao, Lin Chen, Yue Yu, Dongxu Wang, et al., Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: Current understanding and future perspectives. Food Chemistry. 2022, 399:133959. (SCI, JCR Q1, 中科院农林科学1区, IF 9.231#)

11) Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, et al., L-Theanine inhibits (-)-wpigallocatechin-3-gallate oxidation via chelating copper. Journal of Agricultural and Food Chemistry. 2022, 70(25):7751-7761. (SCI, JCR Q1, 中科院农林科学1区, IF 5.895#)

12) Xiaohong Feng, Longkun Ding, Guifang Ma, Ying Zhang, Yefu Sun, Zhengzhang Li, Xiaojun Tao, Asmaa Ali, Dongxu Wang*, et al., Lactobacillus rhamnosus TR08 improves dyslipidemia in mice fed with a high fat diet via regulating the intestinal microbiota, reducing systemic inflammatory response and promoting sphingomholipid metabolism. Molecules. 2022, 27(21), 7357. (SCI, JCR Q2, 中科院化学2区, IF 4.927#)

13) Wenjing Liao, Suyu Liu, Yunxi Chen, Yashuai Kong, Dongxu Wang, et al., Effects of Keemun and Dianhong black tea in alleviating excess lipid accumulation in the liver of obese mice: A comparative study. Frontiers in Nutrition. 2022, 9:849582. (SCI, JCR Q1, 中科院农林科学2区, IF 6.59#)

14) Nora Pap, Marina Fidelis, Luciana Azevedo, Mariana Araújo Vieirado Carmo, Dongxu Wang, et al., Berry polyphenols and human health: evidence of antioxidant, anti-inflammatory, microbiota modulation, and cell-protecting effects. Current Opinion in Food Science. 2021, 42:167-186. (SCI, JCR Q1, 中科院农林科学2区, IF 9.8#)

15) Dongxu Wang, et al., Green tea polyphenols mitigate plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways, Food and Chemical Toxicology. 2020, 144:111576. (SCI, JCR Q1, 中科院食品科技2区, IF 6.025#)

16) Dongxu Wang, et al., Ameliorative effects of L-theanine on dextran sulfate sodium induced colitis in C57BL/6J mice are associated with the inhibition of inflammatory responses and attenuation of intestinal barrier disruption, Food Research International. 2020, 137:109409. (SCI, JCR Q1, 中科院食品科技1区, IF 6.475#)

17) Dongxu Wang, et al., Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation, Food Research International. 2020, 127:108628. (SCI, JCR Q1, 中科院食品科技1区, IF 6.475#)

18) Jinbao Huang, Wenjiao Li, Wenjing Liao, Qing Hao, Dongxu Wang, et al., Green tea polyphenol (-)-epigallocatechin-3-gallate alleviates non-alcoholic fatty liver disease and ameliorates intestinal immunity in mice fed a high fat diet, Food & Function. 2020, 11(11):9924-9935. (SCI, JCR Q1, 中科院农林科学1区, IF 5.396#)

19) Dongxu Wang, et al., Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation, Food & Function. 2019, 10:3898-3908. (SCI, JCR Q1, 中科院农林科学1区, IF 4.171#)

20) Dongxu Wang, et al., Anticancer activity and mechanism of total saponins from the residual seed cake of Camellia oleifera Abel. in hepatoma-22 tumor-bearing mice, Food & Function. 2019, 10:2480-2490. (SCI, JCR Q1, 中科院农林科学1区, IF 4.171#)

21) Dongxu Wang, et al., Protective effect and mechanism of theanine on lipopolysaccharide-induced inflammation and acute liver injury in mice, Journal of Agricultural and Food Chemistry. 2018, 66:7674-7683. (SCI, JCR Q1, 中科院农林科学1区, IF 3.571#)

22) Dongxu Wang, et al., Theanine supplementation prevents liver injury and heat shock response by normalizing hypothalamic-pituitary-adrenal axis hyperactivity in mice subjected to whole body heat stress, Journal of Functional Foods. 2018, 45:181-189. (SCI, JCR Q1, 中科院食品科技2区, IF 3.197#)

23) Yijun Wang, Zhipeng Kan, Dongxu Wang, et al., Differences in chemical composition among commercially important cultivars of Genus Camellia. Journal of Agricultural and Food Chemistry. 2018, 67:5457-5464. (SCI, JCR Q1, 中科院农林科学1区, IF 3.571#)

24) Dongxu Wang, et al., Green tea infusion protects against alcoholic liver injury by attenuating inflammation and regulating PI3K/Akt/eNOS pathway in C57BL/6 mice, Food & Function. 2017, 8:3165-3177. (SCI, JCR Q1, 中科院农林科学1区, IF 3.289#)

25) Ruixia Dong, Dongxu Wang, et al., Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice, Redox Biology. 2016, 10:221-232. (SCI, JCR Q1, 中科院生物学1区, IF 6.337#)

26) Jianfa Zong, Dongxu Wang, et al., Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: a novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro, RSC Advances. 2016, 6, 91386. (SCI, JCR Q2, 中科院化学3区, IF 3.108#)

27) Yaqing Wei, Pingping Chen, Tiejun Ling, Yijun Wang, Ruixia Dong, Chen Zhang, Longjie Zhang, Manman Han, Dongxu Wang, et al., Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG, Food Chemistry. 2016, 204:218-226. (SCI, JCR Q1, 中科院食品科技1区, IF 4.529#)

28) Manman Han, Guangshan Zhao, Yijun Wang, Dongxu Wang, et al., Safety and anti-hyperglycemic efficacy of various tea types in mice, Scientific Reports. 2016, 6:31703. (SCI, JCR Q2, 中科院综合3区, IF 4.259#)

29) Dongxu Wang, et al., Melatonin attenuates (-)-epigallocatehin-3-gallate -triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice, Journal of Pineal Research. 2015, 59(4):497-507. (SCI, JCR Q1, 中科院医学生理学1区, IF 9.314#)

30) Dongxu Wang, et al., Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: Responses of major antioxidant enzymes and the Nrf2 rescue pathway, Toxicology and Appllied Pharmacology. 2015, 283(1):65-74. (SCI, JCR Q1, 中科院药学毒理学2区, IF 3.847#)

31) Shanshan Wu, Kang Sun, Xin Wang, Dongxu Wang, et al., Protonation of epigallocatechin-3-gallate (EGCG) results in massive aggregation and reduced oral bioavailability of EGCG-dispersed selenium nanoparticles, Journal of Agricultural and Food Chemistry. 2013, 61(30):7268-7275. (SCI, JCR Q1, 中科院农林科学1区, IF 3.107#)

32) Dongxu Wang, et al., Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention, International Journal of Nanomedicine. 2012, 7:1711-1721. (SCI, JCR Q1, 中科院工程技术1区, IF 4.976#)